Abstract
The three-component Biginelli reaction using aldehyde, thiourea, and 1,3-dicarbonyl compounds was performed smoothly in ethyl lactate (EL) with the catalysis of trimethylsilyl chloride (TMSCl). A class of 3,4-dihydropyrimidinthiones (DHPMs) were synthesized in good to excellent yields via the bio-based solvent mediated catalytic protocol.
GRAPHICAL ABSTRACT
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FUNDING
Financial support from NSFC (no. 21202064), a sponsored project from Jiangxi Provincial Department of Education (no. GJJ12211) are gratefully acknowledged.