Efficient Synthesis, Characterization, and Antibacterial Activity of Novel N-Acylsulfonamides and Sulfonylureas

GRAPHICAL ABSTRACT

Abstract

A series of novel sulfonylureas and N-acylsulfonamides derivatives were synthesized and characterized by ¹H NMR, ¹³C NMR, and HRMS. These compounds were synthesized efficiently in two steps (carbamoylation-sulfamoylation), using chlorosulfonyl isocyanate that was a suitable reagent for allowing the introduction of a sulfonamide moiety. The antibacterial activity (in vitro) of some newly formed compounds were investigated against some Gram-positive and Gram-negative bacteria by applying the method of dilution and minimal inhibition concentration methods. These compounds have significant bacteriostatic activity with totalities of bacterial strains used.

Keywords:

• Acylsulfonamides
• sulfonylurea
• antibacterial activity
• chlorosulfonyl isocyanate, MIC

Additional information

Funding

This work was generously supported by the General Directorate for Scientific Research and Technological Development (DG-RSDT), Algerian Ministry of Scientific Research, National Fund of Research (FNR). We also thank Christian PERIGAUD and Suzzane PEYRROTES the university of Montpellier II for their help in the identification for all products in NMR and MS.