A Fast Catalytic Process of Transfer of a Phosphorus Atom: How Folding of the Reagent is Related to its Catalytic Activity. A Possible Correlation with Rna Behavior

Abstract

A simple and very fast process of transfer of a phosphorus atom, performed by a simple molecule acting as catalyst in an almost infinite catalytic cycle is described. The catalyst donates a P atom to a mixture of two different Grignard reagents giving, in a very fast and in a highly selective manner, only one phosphorus-containing compound with an enormous rate enhancement with respect to the corresponding no-catalyzed reaction which gives a final cluttered mixture of many organophosphorus products. The focal factor to explain this highly selective process of P transport lies in the folded structure of the reagent with particular angles around the phosphorus atom which can facilitate the formation of cyclic trigonal bipyramidal pentacoordinated species and then its catalytic activity. In a similar manner, RNA can adopt, in a precise position, a particular three-dimensional structure that might facilitate the formation of pentacoordinated species leading to the catalytic function.

GRAPHICAL ABSTRACT

Keywords:

• Phosphorus pentacoordinate
• phosphorus trichloride
• Grignard reagents
• benzothiadiphosphole
• RNA

Additional information

Funding

Work supported by ALMA MATER STUDIORUM–UNIVERSITA’ DI BOLOGNA (ex 60% MIUR).