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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 189, 2014 - Issue 11
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Original Articles

Synthesis, Anti-Inflammatory, and Analgesic Evaluation of Some 2-Amino-5-Selenothiazoles

Moustafa A. GoudaDepartment of Chemistry, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt;Department of Chemistry, Faculty of Science and Arts, Ulla, Taibah University, Kingdom of Saudi ArabiaCorrespondence[email protected]
,
Yousery El-Sayed SherifDepartment of Chemistry, Faculty of Science and Arts, Ulla, Taibah University, Kingdom of Saudi Arabia;Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
&
Mohamed S. ElsherbiniDepartment of Chemistry, Faculty of Science, Al Jouf University, Sakaka, Kingdom of Saudi Arabia
Pages 1633-1643 | Received 23 Jul 2013, Accepted 26 Nov 2013, Published online: 16 Oct 2014
 
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GRAPHICAL ABSTRACT

Abstract

Treatment of 2-aminothiazole (1) with triselenium dicyanide (2) afforded selenocyanate (3). Reduction of 3 with NaBH4 gave the diselenide 4. Compounds 3 and 4 were used as a key intermediate for the synthesis of a series of 2-amino-5-selenothiazoles. The newly synthesized compounds were evaluated as anti-inflammatory and analgesic agent.

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