Nano-Mgo-Catalyzed One-Pot Synthesis of Phosphonate Ester Functionalized 2-Amino-3-Cyano-4H-Chromene Scaffolds at Room Temperature

Abstract

A facile and efficient protocol for one-pot three-component synthesis of structurally diverse (2-amino-3-cyano-4H-chromen-4-yl)phosphonic acid diethyl esters from the reaction of salicylaldehydes, malononitrile (or ethyl cyanoacetate), and triethylphosphite using basic nanocrystalline MgO as catalyst in aqueous ethanolic medium at room temperature has been developed. Nano-MgO has been prepared using a simple sol-gel approach. Clean reaction profile, easy reusability of MgO nano-catalyst, mild reaction condition, good yields, and practical applicability are the major advantages of the present protocol.

GRAPHICAL ABSTRACT

Keywords:

• Multicomponent reaction
• (2-amino-3-cyano-4H-chromen-4-yl)phosphonic acid diethyl esters
• nanocrystalline MgO
• room temperature

Additional information

Funding

Financial assistance from CSIR [Grant No. 02(0110)/12/EMR-II], New Delhi is gratefully acknowledged. S.L. is grateful to the CSIR, New Delhi for awarding him a Senior Research Fellowship. Financial support from DST under FIST program is also acknowledged.