Microwave-Assisted Pd-Catalyzed Desulfitative C—S Coupling of Arylsulfinate Metal Salts and Alkanethiols

GRAPHICAL ABSTRACT

Abstract

This paper reports a palladium-catalyzed C-S coupling of arylsulfinate metal salts and alkanethiols via liberation of sulfur dioxide. The use of PdCl₂ as the catalyst in combination with AgNO₃ as the oxidant under microwave irradiation results in the synthetically and biologically important aryl alkyl sulfides. A variety of arylsulfinate metal salts, such as sodium, potassium, lithium, silver, zinc, and copper salts, are tolerated well in this reaction.

Keywords:

• Desulfitative coupling
• C-S coupling
• arylsulfinate metal salts
• thiols