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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 190, 2015 - Issue 2
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Original Articles

Synthesis, Anticancer and Antioxidant Activity of Novel Carbazole-based Thiazole Derivatives

Minh An Tran NguyenDepartment of Chemistry, Dongguk University-Gyeongju, 123 Dongdae-ro, Gyeongju, Gyeongbuk, Republic of Korea;The Faculty of Chemical Engineering, Industrial University of Ho Chi Minh, Ho Chi Minh City, Viet Nam
,
Anil Kumar MungaraDepartment of Chemistry, Dongguk University-Gyeongju, 123 Dongdae-ro, Gyeongju, Gyeongbuk, Republic of Korea
,
Jung-Ae KimCollege of Pharmacy, Yeungnam University, Gyeongsan712-749, Republic of Korea
,
Kap Duk LeeDepartment of Chemistry, Dongguk University-Gyeongju, 123 Dongdae-ro, Gyeongju, Gyeongbuk, Republic of Korea
&
Soonheum ParkDepartment of Chemistry, Dongguk University-Gyeongju, 123 Dongdae-ro, Gyeongju, Gyeongbuk, Republic of KoreaCorrespondence[email protected]
Pages 191-199 | Received 23 Dec 2013, Accepted 27 Mar 2014, Published online: 06 Jan 2015
 
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GRAPHICAL ABSTRACT

Abstract

A series of carbazole-based thiazole derivatives were synthesized and characterized. The title compounds were evaluated for their cytotoxicity against three cancer cell lines A549, MCF-7, and HT29 by MTT assay. Among several thiazole derivatives, compounds 4-(4-bromophenyl)-2-(2-((9-ethyl-9H-carbazol-3-yl)methylene)hydrazinyl)thiazole (3f) and 2-(2-((9-ethyl-9H-carbazol-3-yl)methylene)hydrazinyl)-4-(4-nitrophenyl)thiazole (3g) are found to display significant cytotoxicity against three cancer cell lines. These compounds have also been tested for antioxidant activity and are found to exhibit higher antioxidant activity than that of the standard BHT.

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