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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 190, 2015 - Issue 5-6: 20th International Conference on Phosphorus Chemistry (ICPC-2014)
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Original Articles

Synthesis and Biological Evaluation of a Phosphonate Phosphoantigen Prodrug

Chia-Hung Christine HsiaoDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA
,
Xiaochen LinDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA
,
Rocky J. BarneyDepartment of Chemistry, University of Iowa, Iowa City, Iowa, USA;Department of Chemistry, Western Wyoming Community College, Rock Springs, Wyoming, USA
,
Rebekah R. ShippyDepartment of Chemistry, University of Iowa, Iowa City, Iowa, USA
,
Jin LiDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA
,
Olga VinogradovaDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA
,
David F. WiemerDepartment of Chemistry, University of Iowa, Iowa City, Iowa, USA;Department of Pharmacology, University of Iowa, Iowa City, Iowa, USA
&
Andrew J. WiemerDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USACorrespondence[email protected]
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Pages 751-753 | Received 30 Aug 2014, Accepted 23 Sep 2014, Published online: 01 Jul 2015
 
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GRAPHICAL ABSTRACT

Abstract

We have recently reported the synthesis of the first known phosphoantigen prodrug, and have demonstrated excellent gains in potency through delivery of the phosphoantigen to the intracellular domain of BTN3A1.

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