GRAPHICAL ABSTRACT
Abstract
During the synthesis of cationic lipids that included thiophosphoramidate moiety or pincer ligands based on O,O-diethyl-thiophosphonate as coordination group, the rearrangement of O,O-diethyl-thiophosphoryl in O,S-diethylthiophosphoryl group was observed. This rearrangement, which does not occur by a simple heating at 130°C, is catalyzed by nucleophilic amine like N,N-dimethylaminopyridine. However, at some occasion, dealkylation of the O,S-diethylthiophosphoryl compound is observed.