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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 190, 2015 - Issue 5-6: 20th International Conference on Phosphorus Chemistry (ICPC-2014)
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Original Articles

A Convenient Procedure for the Synthesis of 2,2,2-Trifluoroethyl Methyl 2-Oxoalkylphosphonates

Katalin MolnárSanofi/Chinoin—Prostaglandin Business Unit, Budapest, HungaryCorrespondence[email protected]
,
Julien BehraNational Graduate School of Chemistry and Chemical Engineering of Montpellier, Montpellier, France
,
László TakácsSanofi/Chinoin—Prostaglandin Business Unit, Budapest, Hungary
,
Mihály KádárSanofi/Chinoin—Prostaglandin Business Unit, Budapest, Hungary
,
Zsuzsanna KardosSanofi/Chinoin—Prostaglandin Business Unit, Budapest, Hungary
&
Ferenc FaiglMTA-BME Organic Chemical Technology Research Group, Hungarian Academy of Sciences, Budapest University of Technology and Economics, Budapest, Hungary
Pages 677-680 | Received 29 Aug 2014, Accepted 13 Oct 2014, Published online: 01 Jul 2015
 
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GRAPHICAL ABSTRACT

Abstract

A convenient and versatile method was developed for the synthesis of 2,2,2-trifluoroethyl methyl 2-oxoalkylphosphonates starting from dimethyl phosphonates by alkaline hydrolysis followed by esterification with 2,2,2-trifluoroethanol using diisopropylcarbodiimide (DIC) in the presence of 4-(dimethylamino)pyridine (DMAP) catalyst following the Steglich protocol.

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