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Original Articles

Synthesis of a New Class of Phosphonate Derivatives Using a Three Component Reaction of Trialkyl Phosphites or Triaryl Phosphites in Water

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Pages 1177-1182 | Received 08 Sep 2014, Accepted 15 Oct 2014, Published online: 25 Jul 2015
 

GRAPHICAL ABSTRACT

Abstract

A simple, rapid, efficient, and environmental method for the preparation of phosphonate derivatives has been realized using the reaction of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, malononitrile or ethyl cyanoacetate, and trialkyl phosphites or triaryl phosphites in water as the solvent at room temperature.

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