A One-Pot, fast, and efficient amidation of carboxylic acids, α-amino acids and sulfonic acids using pph₃/n-chlorobenzotriazole system

GRAPHICAL ABSTRACT

Abstract

Triphenylphosphine (PPh₃)/N-chlorobenzotriazole (NCBT), and amine (primary and secondary aliphatic amines and also substituted anilines) in CH₂Cl₂ efficiently converted carboxylic acids, α-amino acids, and sulfonic acids to the corresponding amides and sulfonamides at room temperature. Good to excellent yields, inexpensive, and fast reaction conditions are the important features of this procedure.

Keywords:

• Amidation
• carboxylic acid
• amino acid
• sulfonic acid
• triphenylphosphine
• N-chlorobenzotriazole
• one-pot synthesis