Synthesis, Antioxidant, Anti-Inflammatory, and Antimicrobial Screening of Newer Thiophene-Fused Arylpyrazolyl 1,3,4-Oxadiazoles

GRAPHICAL ABSTRACT

Abstract

A series of newer 1,3,4-oxadiazole derivatives 3a–h, 5a–h containing a thiophene fused with pyrazole moiety of pharmacological significance have been synthesized. The compounds were characterized by ¹H NMR, IR, and mass spectral techniques. The compounds were screened for their in vitro antioxidant, anti-inflammatory and antimicrobial activities. Among them, Compounds 3b (EC₅₀–14.98) and 3f (EC₅₀–12.21) showed significant antioxidant activity. Compound 3a (EC₅₀–15.23) showed good anti-inflammatory activity. Compound 3d was found as the most active derivative against bacterial and fungal strains.

Keywords:

• Thiophene-fused pyrazole
• 1,3,4-oxadiazole
• antioxidant
• anti-inflammatory
• antimicrobial
• EC₅₀

ACKNOWLEDGMENTS

The authors are also thankful to the Head, Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, for providing research facilities. We are also thankful to the Haffkine research institute for providing biological activities.