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GRAPHICAL ABSTRACT
Abstract
A new method for the synthesis of organophosphorylated adducts of the nonapeptide FGESAGAAS is presented. The adducts were obtained by using sarin (GB) or soman (GD) as the organophosphorylating reagents and cesium carbonate as the acid scavenger. Greater than 50% of the peptide was modified on serine 4. MS/MS spectra acquired on an Agilent 6520 quadrupole time of flight mass spectrometer demonstrated that serine 4, but not serine 9 in the nonapeptide, was modified. The adducts included the characteristic isopropyl group of sarin and the pinacolyl group of soman, indicating that aging had not occurred. It was concluded that the new synthetic method yielded sarin and soman-modified peptides that could be used as references when analyzing human exposure to these nerve agents.