Design, green synthesis, anti-microbial, and anti-oxidant activities of novel α-aminophosphonates via Kabachnik-Fields reaction

GRAPHICAL ABSTRACT

ABSTRACT

An efficient and environmentally friendly protocol has been developed for the synthesis of novel α-aminophosphonates in good to excellent yields (76–92%) by a one-pot, three-component reaction of an amine, an aldehyde, and diphenyl phosphite using polyethylene glycol (PEG-400) as a green solvent at 80°C via Kabachnik-Fields reaction. Their chemical structures were elucidated by IR, ¹H, ¹³C, and ³¹P NMR spectroscopy, mass spectrometry, and elemental analysis. The titled compounds displayed moderate to high anti-microbial and anti-oxidant activities.

KEYWORDS:

• α-Aminophosphonates
• Kabachnik-Fields reaction
• green synthesis
• anti-microbial activity
• anti-oxidant activity

Acknowledgments

The authors are thankful to Andhra Loyola Institute of Engineering and Technology, Vijayawada, Andhra Pradesh, India, for the encouragement.

Funding

The authors are grateful to National Research Foundation (NRF), South Africa, and the University of Zululand, South Africa, for financial support.