Abstract
An efficient green protocol for the synthesis of 1,3,4-oxadiazoles derivatives via a one-pot three-component reaction of aromatic carboxylic acids, N-isocyanimino-triphenylphosphorane and ester derivatives of 2-oxopropyl alcohol (2-oxopropyl benzoate, 2-oxopropyl-4-bromobenzoate and 2-oxopropyl acetate) in water at room temperature have been developed. The present methodology offers several advantages such as a simple procedure, high yields, environmental friendliness and the absence of any volatile and hazardous organic solvents.