Heterocyclic synthesis using the intramolecular Mannich cyclization reaction and enantiopure N-sulfinyl β-amino carbonyl compounds

GRAPHICAL ABSTRACT

Abstract

This mini review summaries applications of N-sulfinyl imine derived β-amino carbonyl compounds, Mannich bases, for the asymmetric synthesis of heterocyclic alkaloids, including piperidines, quinolizidines, indolizidines, tropinones, and homotropinones, using the intramolecular Mannich cyclization reaction.

Keywords:

• Asymmetric synthesis
• intramolecular Mannich cyclization
• β-amino carbonyl compounds
• alkaloids
• piperidines
• quinolizidines
• indolizidines
• tropinones
• homotropinones

Funding

This work was supported by grants from the National Institutes of General Medical Sciences and Temple University.