Multiple stereoselectivity in organophosphorus chemistry

GRAPHICAL ABSTRACT

ABSTRACT

Strategy of multiple stereoselectivity is an effective method for stereochemical control in asymmetric synthesis of organic compounds. Multiple stereoselectivity gets increasingly wide dissemination in organic chemistry, and also in organophosphorus chemistry. The particular interest represents the cooperative catalysis, consisting in introduction of several chiral centers into a ligand, or cooperation of two different catalysts in one reaction process. Therefore, the data concerning of application of multiple stereoselectivity for preparation of chiral organophosphorus compounds were generalized and described in the review.

KEYWORDS:

• Stereoselectivity
• double asymmetric induction
• stereodifferentiation
• phospha-aldol reaction
• phospha-Mannich reaction
• asymmetric reduction