A simple and efficient approach to the synthesis of 1-phosphonated 5-amino-1-H-[1,2,4]-triazole from N-functionalized imidates

ABSTRACT

In this study, we describe a new and easy synthetic approach to variously substituted triazoles based on the reaction of imidates with phosphorylated hydrazine in good yields. A general mechanism of the reactions was also proposed. Characterization of the products was carried out by several analytical and spectroscopic tools including infrared and nuclear magnetic resonance spectroscopies (¹H, ¹³C NMR, ³¹P NMR).

GRAPHICAL ABSTRACT

KEYWORDS:

• (Thio)phosphohydrazides
• N-functionalized imidates
• 1-phosphonated-5-amino-1-H-[1,2,4]-triazole