Nano Gd₂O₃ catalyzed synthesis and anti-oxidant activity of new α-aminophosphonates

GRAPHICAL ABSTRACT

ABSTRACT

A one pot three-component nano Gd₂O₃ catalyzed neat reaction of 2-morpholinoethanamine and dimethylphosphite with various salicylaldehydes under microwave irradiation afforded a series of new α-aminophosphonates in high yields. The synthesized compounds were characterized by FT-IR, (¹H, ¹³C, ³¹P)-NMR, and mass spectral methods. The antioxidant activity of these compounds was evaluated against DPPH, NO, and H₂O₂ methods and found that the compound Dimethyl (2-hydroxy-5-nitrophenyl) (2-morpholinoethylamino) methylphosphonate (4h) has higher antioxidant activity than the corresponding standards.

KEYWORDS:

• α-Aminophosphonate
• nano Gd₂O₃
• antioxidant activity
• 2-morpholinoethanamine

Acknowledgments

The authors express their grateful thanks to Prof. C. Devendranath Reddy, Department of Chemistry, Sri Venkateswara University, Tirupati, for his helpful discussions.

Funding

The authors express their grateful thanks to the Council of Scientific and Industrial Research (CSIR), New Delhi, India for providing financial assistance (Sanction. Lt. No. : 02(0137)/13/EMR-II, Dated 12-04-2013).