Overview on the recently developed thiazolyl heterocycles as useful therapeutic agents

GRAPHICAL ABSTRACT

ABSTRACT

Thiazoles are important heterocyclic compounds which have many biological activities and different applications such as useful ligands, in optical sensors, etc. A literature survey shows that there are different routes to thiazoles. One of the most frequently used synthetic approaches consists of a reaction between α-halocarbonyl compounds with a CSNH₂ moiety. In this mini-review we have classified the contents based on the reagent or material providing the sulfur atom of the thiazole ring. Also, among many articles which have been devoted to thiazole syntheses here we presented some synthetic approaches published from 2012 to 2014.

KEYWORDS:

• Aminothiophenol
• isothiocyanates
• thiazole
• thiosemicarbazide
• thiourea