Willgerodt–Kindler reaction-driven one pot solventless entry to 2-oxazolines

GRAPHICAL ABSTRACT

ABSTRACT

We report an efficient and green protocol for the synthesis of 2-oxazolines by the reaction of aromatic nitriles with β-aminoalcohols using sulfur under solvent-free conditions. The reaction occurs via the Willgerodt–Kindler mechanism followed by transamidation and dehydrosulfuration. This methodology offers several advantages such as good yields, mild and practical reaction conditions, simple work-up procedure, and broad substrate scope, which makes the process simple, convenient, and environmental-friendly.

KEYWORDS:

• β-Aminoalcohol
• oxazoline
• sulfur
• solvent-free condition
• Willgerodt–Kindler reaction

Acknowledgments

We are thankful to the Head, School of Studies in Chemistry and Central Library of Jiwaji University, Gwalior, Madhya Pradesh, India for providing necessary facility and support for this work.