ABSTRACT
AgBF4 catalyzed Mannich-type reactions of siyl dienolate with chiral aryl-substituted (S)-N-tert-butanesulfinylimines has been developed. A class of chiral trans α-vinyl-β-amino esters was obtained in moderate to excellent yields (up to 93%), good diastereoselectiveties (up to 92:8 dr), and complete α-site regioselectivity.
Funding
We thank Sichuan University of Science & Engineering (No. 2014RC07), Science and Technology Department of Sichuan Province (No. 2016JY0246), Zigong Science and Technology Bureau (No. 2015SF02) and Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education (No. LZJ1505) are also greatly acknowledged for funding this work.