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GRAPHICAL ABSTRACT
ABSTRACT
An efficient, green, rapid multitasking protocol for the selective C-5 substitution of 2-aminothiazole using iodic acid and aqueous PEG-400 was developed. The method found suitable for C-5 substitution i.e. iodination and thiocyanation of 2-amino thiazole using iodine and ammonium thiocyanate respectively. Iodic acid was found to be a good oxidant and aqueous PEG-400 as green reaction solvent.
Funding
The authors PPM and RDK are sincerely thankful to the UGC-CSIR, New Delhi for JRF Award no. F. 17-3/2007 (SA-I). Authors ANA and SNK acknowledge UGC, New Delhi for FIP Under FDP Programm award F. No. 36-33/14 (WRO) and F. No. 38-07/14 (WRO).