Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents

GRAPHICAL ABSTRACT

ABSTRACT

A series of tri-substituted thiourea derivatives were synthesized by the reaction of 1,3,5-triacetylbenzoyl isothiocyanate with aminoacids and aniline derivatives. All thiourea derivatives were characterized by FT-IR, ¹H and ¹³C NMR spectroscopy. Antibacterial activities against wild-type Escherichia coli American Type Culture Collection 8739 were determined by use of the turbidimetric methodto evaluate the effect of varying amino groups on the synthesized thioureas. Tris-thiourea derivatives bearing ortho-chloroaryl substituents showed excellent antibacterial activity against E. coli with minimal inhibitory concentration (MIC) of 96 ppm. The optimum inhibition was dependent on the type of amines and the position of the halogen in aniline.

KEYWORDS:

• Antibacterial activity
• amino acid
• tris-thiourea

Funding

The authors would like to thank the Universiti Malaysia Sarawak and the Ministry of Higher Education for financial support through FRGS/ST01(01)/1298/2015(15) and C09/SpSTG/1359/16/1.