Multicomponent reactions for the synthesis of new cyclopentadienephosphonate derivatives in water

GRAPHICAL ABSTRACT

ABSTRACT

A series of polysubstituted cyclopentadienephosphonate derivatives were synthesized via one-pot multicomponent reactions of primary amines and phosphites with activated acetylenic compounds in water as the solvent at room temperature.

Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and a straightforward procedure.

KEYWORDS:

• Phosphonate
• primary amines
• cyclopentadiene
• phosphites
• activated acetylenic compound