ABSTRACT
The 1:1 imine intermediate created by the addition of a primary amine to a cyclic ketone is trapped by N-isocyaniminotriphenylphosphorane (Ph3PNNC) in the presence of ferrocene carboxylic acid and the corresponding iminophosphorane intermediate was formed. Afterwards, ferrocene containing 1,3,4-oxadiazole derivatives are formed via intramolecular aza-Wittig reaction of the iminophosphorane intermediate. The reaction proceeded under mild conditions at room temperature.
Funding
This work is funded by the grant NRF-2015-002423 of the National Research Foundation of Korea.