ABSTRACT
Three novel cyclotriphosphazene derivatives were synthesized by the reaction of hexachlorocyclotriphosphazene (HCCP) with (S)-BINOL and the potassium salt of 4-hydroxybenzaldehyde, and subsequent reduction of aldehyde groups to alcohol groups using sodium borohydride. The bromination reaction was carried out using PBr3 to give N3P3(O2C20H12)(OC6H4-p-CH2Br)4 (3). The target ligands were obtained by the reaction of compound 3 with morpholine, imidazole, and pyrazole, respectively. Structure of title compounds were characterized by 1H NMR, 13C NMR, 31P NMR, and ESI-MS. The Cu complex of 4 was effective in the cleavage of pUC19 DNA under physiological conditions.
Funding
This work was financially supported by the NSFC (no. 21572209), He'nan Scientific Committee (152102410018), and Foundation of He'nan Educational Committee.