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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 191, 2016 - Issue 11-12: 21st International Conference on Phosphorus Chemistry (ICPC-2016)
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Original Articles

Glyco-phospho-glycero-ether lipid as modulator of SK3 ion channel and SK3-dependent cancer cell migration

C. M. SevrainCEMCA, UMR CNRS 6521, Université de Brest, IBSAM, BREST, France;Network “Ion channels and cancer”-Canceropôle Grand Ouest, (IC-CGO)France
,
W. BertheCEMCA, UMR CNRS 6521, Université de Brest, IBSAM, BREST, France;Network “Ion channels and cancer”-Canceropôle Grand Ouest, (IC-CGO)France
,
H. Couthon-GourvèsCEMCA, UMR CNRS 6521, Université de Brest, IBSAM, BREST, France;Network “Ion channels and cancer”-Canceropôle Grand Ouest, (IC-CGO)France
,
J. P. HaeltersCEMCA, UMR CNRS 6521, Université de Brest, IBSAM, BREST, France;Network “Ion channels and cancer”-Canceropôle Grand Ouest, (IC-CGO)France
,
A. M. BouchetNetwork “Ion channels and cancer”-Canceropôle Grand Ouest, (IC-CGO)France;Inserm, UMR 1069, Université François Rabelais Tours, France
,
A. ChantômeNetwork “Ion channels and cancer”-Canceropôle Grand Ouest, (IC-CGO)France;Inserm, UMR 1069, Université François Rabelais Tours, France
,
M. Potier-CartereauNetwork “Ion channels and cancer”-Canceropôle Grand Ouest, (IC-CGO)France;Inserm, UMR 1069, Université François Rabelais Tours, France
,
C. VandierNetwork “Ion channels and cancer”-Canceropôle Grand Ouest, (IC-CGO)France;Inserm, UMR 1069, Université François Rabelais Tours, France
&
P. A. JaffrèsCEMCA, UMR CNRS 6521, Université de Brest, IBSAM, BREST, France;Network “Ion channels and cancer”-Canceropôle Grand Ouest, (IC-CGO)FranceCorrespondence[email protected]
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Pages 1623-1624 | Received 22 Jul 2016, Accepted 22 Jul 2016, Published online: 17 Aug 2016
 
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GRAPHICAL ABSTRACT

ABSTRACT

In this short review paper, we report our efforts to design new inhibitors of SK3 ion channel that are involved in cancer cell migration and metastases formation. The originality of the new SK3 inhibitors comes from their amphiphilic nature and contrast form others inhibitors that are peptides or heterocyclic compounds. We found that ether lipids and ether phospho-glyco-lipids are indeed efficient to modulate SK3 ion channel that consequently reduced cancer cell migration (in vitro assays) and abolished the formation of bone metastases in a murine model of breast cancer.

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