Silica iodide catalyzed, ultrasound-promoted, one-pot four-component synthesis of novel 1,4,5,6-tetrahydropyridine-3-carboxylate derivatives

GRAPHICAL ABSTRACT

ABSTRACT

Silica iodide catalyzed, competent synthesis of 15 novel substituted-1,4,5,6-tetrahydropyridine-3-carboxylate derivatives was achieved by a one-pot four-component cyclocondensation of Meldrum's acid, aryl aldehydes, aromatic amines and ethyl acetoacetate under ultrasonic irradiation. In comparison to the conventional methods, our protocol is convenient, eco-friendly and offers several benefits such as: mild conditions, high yields, shorter reaction time and ease in product isolation.

KEYWORDS:

• One-pot four-component synthesis
• silica iodide
• ultrasonic irradiation
• solvent-free reaction
• 1,4,5,6-tetrahydropyridine-3-carboxylates

Funding

The authors gratefully acknowledge the financial assistance by the VGST, Dept. of IT, BT and Science & Technology, Government of Karnataka for the CESEM Award Grant No. 24 (2010–2011).