338
Views
14
CrossRef citations to date
0
Altmetric
Original Articles

Synthesis of novel thiazolidine-4-one derivatives and their anticancer activity

, , &
Pages 344-350 | Received 21 Jan 2016, Accepted 18 Sep 2016, Published online: 29 Dec 2016
 

GRAPHICAL ABSTRACT

ABSTRACT

This paper describes the synthesis of a novel series of 1,3-thiazolidine-4-ones 6a-n by cycloaddition reaction of N-aryl-N'-acyl thioureas 4a-k with acetylenic esters 5a-b under microwave irradiation and solvent free conditions. Our method, compared to conventional heating conditions has the benefit of higher reaction yield and shorter reaction times. Structural confirmation and characterization of products based on the analytical, chemical, and spectral analysis was confirmed. Cellular investigations showed that the target synthesized thiazolidine-4-ones are toxic and could be used as anticancer agents for MKN-45 gastric adenocarcinoma cells.

Acknowledgments

We acknowledge the useful suggestions made by Professor Douglas Fry of SAFC, USA.

Funding

The partial support of this research by the Research Committee of the University of Guilan and Tonekabon Branch, Islamic Azad University is gratefully acknowledged.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 2,235.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.