GRAPHICAL ABSTRACT
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ABSTRACT
The Bi(NO3)3.5H2O mediated synthesis of α-hydroxyphosphonates via phosphonylation of aldehydes is reported herein. Both conventional and microwave technology was efficiently applied to range of aromatic, heteroaromatic, α,β-unsaturated aldehydes under solvent-free conditions. The solvent free conditions, avoidance of toxic reagents and excellent yield are some of the remarkable features of this protocol to access the medicinally privileged structure, α-hydroxyphosphonates.
Acknowledgment
We are thankful to IIIM Jammu for providing spectra.
Funding
We sincerely thank UGC, New Delhi for its financial support [F. No. 39-788/2010 (SR)].