Microwave-assisted alcoholysis of dialkyl H-phosphonates by diols and amino alcohols

GRAPHICAL ABSTRACT

ABSTRACT

The microwave-assisted alcoholysis of dialkyl H-phosphonates with diols and amino alcohols aiming at P-functionalized monomers was studied. Depending on the conditions (molar ratio, temperature, time), the reaction could be fine-tuned to afford the target mono and bis hydroxyalkyl or aminoalkyl H-phopshonate derivatives. The formation of three types of by-products was also investigated. Thermal accomplishments showed lower efficiency in the transesterifications.

KEYWORDS:

• Alcoholysis
• bifunctional nucleophiles
• H-phosphonate monomers
• microwave
• optimization