Fast and efficient method for Silylation of alcohols and phenols with HMDS in the presence of bis-thiourea complexes of cobalt, nickel, copper and zinc chlorides

GRAPHICAL ABSTRACT

ABSTRACT

Bis-thiourea complexes of cobalt, nickel, copper and zinc chlorides were used efficiently for rapid and efficient trimethylsilylation of alcohols and phenols with hexamethyldisilazane (HMDS) in CH₃CN. All reactions were carried out at room temperature within immediate-120 min timeframe to afford trimethylsilyl ether derivatives in high to excellent yields. Investigation of the results exhibited that the prepared bis-thiourea metal complexes show the activity as Co(tu)₂Cl₂> Ni(tu)₂Cl₂> Cu(tu)₂Cl₂> Zn(tu)₂Cl₂ in their silylation reactions.

KEYWORDS:

• Alcohols
• bis-thiourea
• hexamethyldisilazane
• M^II(tu)₂Cl₂
• phenols
• silylation

Acknowledgments

The authors gratefully appreciated the financial support of this work by the research council of Urmia University.