Potassium phthalimide catalyzed efficient synthesis of 2-Amino-3-phenylsulfonyl-4H-chromenes under Solvent-Free Conditions

GRAPHICAL ABSTRACT

ABSTRACT

An efficient and eco-friendly protocol for the preparation of 2-amino-3-phenylsulfonyl-4H-chromenes employing a three component, one-pot condensation reaction between aromatic aldehydes, phenylsulphonylacetonitrile and 1-naphthol has been developed. The reaction of 1-naphthol with phenylsulphonylacetonitrile and various aromatic aldehydes was carried under solvent-free conditions using 10 mol% of potassium phthalimide as a catalyst to give the corresponding products in good to excellent yields. It was also found that potassium phthalimide can be recycled at least four times without loss of activity. General applicability, operational simplicity, mild reaction conditions, short reaction time, non-toxic, inexpensive and recyclable catalyst, and solvent-free conditions are the advantages of the present procedure.

KEYWORDS:

• potassium phthalimide
• 2-amino-3-phenylsulfonyl-4H-chromene
• multicomponent reactions
• solvent-free

Acknowledgments

We gratefully acknowledge financial support from the Fundamental Research Funds for the Central Universities, South-Central University for Nationalities (CZP17006).

Additional information

Funding

The Fundamental Research Funds for the Central Universities, South-Central University for Nationalities, CZP17006.