Abstract
O, O’-Dialkyl and alkylene dithiophosphatogold (III)dichloride complexes of the type [(RO)2PS2]AuCl2 and [S2POGO]AuCl2, where R = Et, nPr, iPr, iBu, Ph, cyclohexyl and cyclopentyl, where G = CMe2CMe2-, have been synthesized in 80-90% yields by reaction of the corresponding acid or sodium salts of the appropriate dithiophosphoric acids in 1:1 ratio with gold (III) chloride in dry dichloromethane at room temperature. The compounds have been characterized by elemental analyses, IR and (1H, l3C, and 31P) NMR. The crystal structure of [S2POCMe2CMe2O]AuCl2, was determined. These new complexes have shown their growth inhibiting potential against various bacterial strains with moderate to good activity.
Graphical Abstract
![](/cms/asset/7e67956c-b24b-4813-be3b-5a9e9e6e74dc/gpss_a_1521405_uf0001_c.jpg)
Acknowledgments
We thank the Obama Sing fellowship program, Michigan State University, Chemistry Department and Faculty of Engineering in Alabama A&M University for support of this research.
Disclosure statement
No potential conflict of interest was reported by the authors.
Table 1. Crystal data and structure refinement for O, O’-1,1,2,2-tetramethyl ethylene dithiophosphatogold (III)dichloride.