Abstract
Herein we describe our recent advances in the synthesis of new bisphosphonates, containing adenosines, adenine moiety as well as reactive aminoacetal fragment and calix[4]resorcinols framework. For the synthesis of these compounds we used three main approaches: Michael addition of nucleophilic amines (adenosines, adenines and aminoacetaldehyde) to (tetraethyl)ethenylidene-1,1-bisphosphonate and tetrakis(trimethylsilyl)ethenylidene-1,1-bisphosphonate); acid catalyzed condensation of bisphosphonic acid derivatives, containing acetal group with polyphenols; formation of onium salts of bisphosphonic acids with adenosine and aminomethylated calix[4]resorcinols.