Synthesis of vinca alkaloid–triphenylphosphine derivatives having potential antitumor effect

Abstract

The successful therapy of cancer is still unresolved. For that reason enormous efforts are being made to increase the effectiveness of anticancer drugs and reduce their side effects at least. An important approach to the development of selective molecules is the synthesis of drug conjugates, also called as “hybrids”. Taking this into consideration two Vinca alkaloid derivatives conjugated with triphenylphosphine have been synthetized. The incorporation of the mentioned two pharmacophores in the same molecule could amplify the evolving cumulative antineoplastic impact and/or counterbalance the side effects. Thus a development of hybrid anticancer molecules has been started by synthesis of Vinca alkaloid–triphenylphosphine conjugates, which could have higher efficacies and safety profiles than the present drugs available in market.

Graphical Abstract

Keywords:

• Anticancer drugs
• triphenylphosphine
• 17-desacetylvindoline
• dimer alkaloids
• hybrid molecules

Notes

1 MCF-7: breast cancer cell line. It is the acronym of Michigan Cancer Foundation-7.