Thiolate-mediated reductive cyclization: asymmetric total synthesis of (+)-engelharquinone

Abstract

We report herein the asymmetric total synthesis of (+)-engelharquinone and its epoxide by exploiting two key reactions; (1) Rhodium catalyzed asymmetric 1,4-addition and (2) thiolate-mediated reductive cyclization.

Graphical Abstract

Keywords:

• Asymmetric synthesis
• natural product
• reductive cyclization
• thiol
• total synthesis