Modeling of biologically relevant chemical transformations involving thionitrates

Abstract

Thionitrates (RSNO₂) have been proposed as key intermediates in the biotransformation of organic nitrates that have been used as nitric oxide prodrugs. However, thionitrates are usually very labile and model studies on the chemical processes involving thionitrates have been difficult. In this paper, model studies of biologically relevant chemical processes involving thionitrates by taking advantage of a nano-sized molecular cavity are summarized.

Graphical Abstract

Keywords:

• Thionitrates
• organic nitrates
• reactive intermediates
• kinetic stabilization
• molecular cavities

Additional information

Funding

This work was partly supported by a Grant-in-Aid for Scientific Research (B) (No. 15H03776), a Grant-in-Aid for Scientific Research on Innovative Areas “Stimuli-responsive Chemical Species for the Creation of Functional Molecules” (No. 15H00930), and a Grant-in-Aid for Scientific Research (C) (No. 17K05774) from MEXT, Japan.