Synthesis and fungicidal activity of novel 1,2,4-triazole derivatives containing a pyrimidine moiety

Abstract

A series of novel 1,2,4-triazole derivatives containing a pyrimidine moiety were synthesized and their fungicidal activities were evaluated. The preliminary biological test indicated that some of the target compounds exhibited moderate to good fungicidal activities against the tested plant pathogenic fungi compared with the commercial agent. Among them, compounds 9n and 9o exhibited excellent antifungal activity against Phompsis sp., with the half-maximal effective concentration (EC₅₀) values of 25.4 and 31.6 μg/mL, which were even better than the commercial agent of Pyrimethanil (32.1 μg/mL). Meanwhile, compound 9o showed better fungicidal activities against B. dothidea and B. cinerea with 40.1 and 55.1 μg/mL, respectively, in comparison with that of commercial Pyrimethanil (57.6 and 62.8 μg/mL).

Graphical Abstract

Keywords:

• Synthesis
• 1,2,4-triazole derivatives
• pyrimidine
• fungicidal activity

Additional information

Funding

This work was supported by the Natural Science Foundation of the Department of Education of Guizhou Province (NO.: qian jiao he KY word [2016]091), the Guizhou Science and Technology Fund Project (NO.: [2016]1006), National Natural Science Foundation of China (No. 31701821 and 21462010), Guiyang Science and Technology Bureau and Guiyang University Special Project (NO.: GYU-KYZ[2018]01-09) and China Postdoctoral Science Foundation (NO.: 2017M623070).