Synthesis, characterization and biological activities evaluation of novel sulfanyl derivatives

Abstract

A novel series of 1-(3-Methyl-3-mesityl)-cyclobutyl-2-{[5-(2-fluorophenyl)-4-(aryl-alkyl)-4H-[1,2,4]triazol-3-yl]sulfanyl}-ethanone compounds were synthesized by a condensation reaction. The new compounds were characterized by elemental analyses, FT-IR and ¹H, ¹³C NMR techniques. The antioxidant and antibacterial properties of the synthesized compounds were also investigated. The in vitro antioxidant and antibacterial activities of the newly synthesized compounds were measured, and they were found to exhibit significantly high antioxidant activity.

Graphical Abstract

Keywords:

• Sulfanyl compounds
• 1,2,4-Triazole
• IR and NMR spectroscopy
• biological effects

Acknowledgment

The author is grateful to Dr. Akif Evren PARLAK for his support in biological studies.