Synthesis of 2-phenoxyl-2-oxo-1,4,2-oxazaphosphinanes from a three component reaction

Abstract

A one-pot synthetic strategy was developed for the synthesis of heterocyclic 1,4,2-oxazaphosphinanes via a three component Kabachnik-Fields reaction of 2-aminophenol, diphenyl H-phosphonate and carbonyl compounds. Through this newly developed method, 12 organophosphorus heterocycles and 2 related chrysin derivatives were synthesized with high yields. The target compounds were characterized by ¹H, ³¹P and 13C NMR and MS.

Graphical Abstract

Keywords:

• Organophosphorus heterocycles
• 1,4,2-oxazaphosphinanes
• chrysin derivatives
• H-phosphonates
• Kabachnik-Fields reaction

Additional information

Funding

We are grateful to the Zhongjing Scholars Research Funding of Henan University of Chinese Medicine (No. 00104311-2019-28).