Abstract
Different thiols were successfully reacted with benzyl allenoate resulting in E-selective thia-Michael addition product with α,β-unsaturation as confirmed by single crystal x-ray crystallographic analysis. The thia-Michael addition is chemoselective and free amine and alcohol groups were well tolerated. Catalytic triethylamine was required for high conversion. Fair to excellent yields were obtained for a variety of aliphatic, aryl and heteroaryl thiols.
Graphical Abstract
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5. Supplementary data
See the attached supporting information file with detailed experimental procedures and spectra for all compounds. The single crystal X-ray data associated with this article can be found at CCDC repository numbers, 1560208 and 1560209.
Disclosure statement
No potential conflict of interest was reported by the author(s).