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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 196, 2021 - Issue 1
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Research Article

A novel approach toward thioester bond formation mediated by N,N’-diisopropylcarbodiimide in water

Nadia Fattahia Department of Chemistry, University of Zanjan, Zanjan, IranCorrespondence[email protected] [email protected]
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,
Najmeh Varnaseria Department of Chemistry, University of Zanjan, Zanjan, IranView further author information
&
Ali Ramazania Department of Chemistry, University of Zanjan, Zanjan, Iran;b Research Institute of Modern Biological Techniques (RIMBT), University of Zanjan, Zanjan, IranCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-3072-7924View further author information
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Pages 6-12 | Received 05 Mar 2020, Accepted 18 Jul 2020, Published online: 31 Aug 2020
 
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Abstract

A simple and efficient method has been developed for the synthesis of thioesters from carboxylic acids and thiols using N,N'-diisopropylcarbodiimide (DIC). The reactions were carried out in water as an environmentally friendly and green solvent. The developed procedure presents an economic, efficient, mild, and very simple protocol for thioesterification reaction in aqueous media.

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Conflict of interest

The authors hereby declare that, there was no conflict of interest in the present study.

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Funding

This work was supported by “Iran National science Foundation: INSF”.

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