One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones, thiones and 2-selenoxo DHPMs using 1-butyl-3-methylimidazolium hydrogen sulfate as non-halogenated ionic liquid

Abstract

1-Butyl-3-methylimidazolium hydrogen sulfate ([BMIM][HSO₄]) as a non-halogenated ionic liquid (IL) was used for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones or 2-selenoxo DHPMs in a Biginelli type multi-component reaction. By using this ionic liquid, the reaction time was significantly reduced and the products were obtained in good to high yields. Also, in this method, the synthesis of novel 2-selenoxo DHPMs is introduced in the presence of this ionic liquid and their structures were determined by ¹H and ¹³C NMR, FT-IR, and Elemental analysis.

Graphical Abstract

Keywords:

• Multi-component reaction
• three-component reaction
• dihydropyrimidin-2(1H)-ones/thiones
• DHPMs
• [BMIM][HSO₄]

Disclosure statement

On behalf of all authors, the corresponding author states that there is no conflict of interest.