Abstract
This review article, containing 52 references, surveys recent achievements of the use of chlorosulfonyl isocyanate (CSI) in organic synthesis. In particular, the application for the preparation of several bioactive products containing the sulfamoyl moiety, which have been published in the last decade, is summarized.
CSI is a versatile reagent and displays excellent reactivity versus compounds with different functional groups such as amines, alcohols, olefins, carboxylic acids, thiols, epoxides etc. It is, thus, widely used as key intermediate for the insertion of the sulfamoyl moiety in various compounds.
Graphical Abstract
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Acknowledgments
We gratefully acknowledge financial support from General Directorate for Scientific Research and Technological Development (DG-RSDT) and Algerian Ministry of Scientific Research.
Project PRFU Number: B00201UN2301120200006.
Conflict of interest
The authors declare that they have no conflict of interest.