Friedel-Crafts alkylation oxidative cyclization catalyzed by co-oxidation of SeO₂ and FeCl₃: a simple synthesis of benzo[b]furan from acetophenone and anisole

Abstract

A simple one-pot method was developed to complete the α-diphenyl substitution and cyclization of acetophenone using acetophenone and substituted benzene as substrates, and a series of benzofuran derivatives was synthesized efficiently. It had the advantages of medium to excellent yield and easily obtained substrate. Compared with other methods, the method avoids the use of precious metals and cumbersome operations.

GRAPHICAL ABSTRACT

Keywords:

• One-pot
• benzofuran derivatives
• α-diphenyl substitution
• cyclization
• cheap metal

Disclosure statement

There are no conflicts to declare.

Additional information

Funding

We gratefully acknowledge the provincial planning project of Zhejiang provincial science and technology department (LGF19B060005) for financial support.