An improved efficient synthesis of new N-heterocylic, homocyclic and aliphatic dronic acids

Abstract

New N-heterocylic, homocyclic and aliphatic dronic acids were synthesized through an improved facile and versatile route by the reaction of various carboxylic acids with Phosphorus trichloride (PC), phosphorus acid (PA) and methanesulfonic acid under reflux and inert atmosphere. Representatively, the dronic acid derived from stearic acid as a long chained fatty acid was also synthesized. All the obtained compounds were analyzed and characterized by means of FT IR, ¹H, ¹³C and ³¹P NMR spectroscopic techniques. In addition, the compound derived from stearic acid was characterized by means of FT IR and Mass spectrometry due to its insolubility in D₂O and DMSO-d₆.

GRAPHICAL ABSTRACT

Keywords:

• Dronic acid
• ³¹P NMR
• Bisphosphonate
• Phosphorus acid
• Carboxylic acid
• Methanesulfonic acid
• McLafferty rearrangement

Acknowledgement

We would like to thanks the Research Council of Urmia University and Shiraz University of Technology for supporting this work.

Disclosure statement

Authors declare no conflict of interest.