Formation, functionalization and interconversion of sulfur containing functional groups in mechanochemical conditions

Abstract

In the recent three decades, a steadily growing interest in the use of ball milling in organic synthesis has developed. The purpose of this mini-review is to briefly present protocols showing the use of ball milling in the formation and transformation of sulfur-containing functional groups. First, mechanochemical functionalization of sulfur-containing compounds is discussed. The second part devoted to interconversions of sulfur-containing functional groups in mechanochemical conditions summarizes the results on sulfenylation reactions, coupling reactions, redox reactions and condensation reactions. We hope that this review will be a useful addition to the collection of review publications devoted to mechanochemistry and will attract the attention of a wider group of researchers dealing with organosulfur chemistry by drawing attention to the attractive features of mechanochemical protocols.

Graphical Abstract

Keywords:

• Mechanochemistry
• sulfides
• sulfoxides
• sulfones
• oxidation
• asymmetric synthesis
• regioselectivity

Acknowledgements

PP-S thanks for the support from the fund of the National Science Center awarded on the basis of the decision UMO-2015/17/N/ST5/03908 (grant “Preludium”)

Disclosure statement

The authors report no potential conflict of interest.